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Polyphenols can protect cells from oxidative damage by regulating certain cell signaling pathways (e.g., NRF2-KEAP1-ARE or MAPK) and can increase the expression of antioxidant enzymes, such as NQO1 and GST [50]

doi: 10.1002/j.1460-2075.1995.tb00075.x 29 ProvencioI.JiangG.De GripW

ROS are generated during ethanol and acetaldehyde oxidation both by ADH/ALDH and by CYP2E1

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Association between heavy metal exposure and Parkinsons disease: a review of the mechanisms related to oxidative stress