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Creation of a claudin-2 binder and its tight junction-modulating activity in a human intestinal model

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When ischemia-injured jejunum was recovered ex vivo on Ussing chambers in the presence of a single dose of apically administered LA, restoration of barrier function was significantly enhanced in comparison with untreated ischemic controls, as indicated by elevated TEER and decreased mucosal-to-serosal macromolecular flux

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