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The transport mechanism of CLCs has been well established by structural studies which revealed a homodimeric architecture with each protomer bearing a separate ion transport pathway and three consecutive substrate-binding sites referred to as the external site (S ext ), central site (S cen ) and internal site (S int ) 15,16,17,18,19,20,21,22,23,24,25

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The reabsorption of carnitine by the kidney affects the carnitine availability in other organs and maintains the metabolic balance between the kidney and other organs

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