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This transporter has similarities to the cystic fibrosis transmembrane conductance regulator (CFTR), which has been shown to be responsible for GSH flux from lung airway epithelial cells (Kogan et al , 2003), suggesting that ABC transporters might function in the transport of glutathione in mammalian cells

These individuals are at an increased risk from environmental factors, including microbes and food components, interacting with the subepithelial immune system and entering systemic circulation to promote chronic inflammation and tissue damage in multiple extraintestinal sites

PMID: 40309672

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