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Description
Everolimus, a second-generation mTOR inhibitor, modulates T cell proliferation, metabolism, and apoptosis by specifically inhibiting the mTORC1/2 complex (241243)

Several animal model studies suggested a cytoprotective effect for drug-induced gastric mucosal lesions [245,246,247]

Serum homocystein levels were high 45 micromoles/l

Scores of 3, 2, or 3 were not recorded by the investigator or by any of the subjects

While preclinical results are highly promising, human clinical trials have not yet been completed

5-Fluorouracil-resistant CD34+ cell population from peripheral blood of CML patients contains BCR-ABL-negative progenitor cells
