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and C.L., and contributed to manuscript review

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Examples: Ibuprofen, Diclofenac, Naproxen, Aspirin, Indomethacin, Ketoprofen Mechanism of action: Inhibit cyclo-oxygenase (COX-1 and COX-2) enzymes, which block prostaglandin synthesis

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Calculations were performed with Microsoft Excel (365 MSO, Version 2501, Microsoft Corp., Redmond, United States)

Classical homocystinuria: From cystathionine beta-synthase deficiency to novel enzyme therapies

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