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Oncogenic phosphatidylinositol 3-kinase (PI3KCA) mutations activate protein kinase B (AKT), which phosphorylates xCT at serine 26 to suppress cystine/glutamate antiport [5]

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doi: 10.1016/j.jhep.2016.04.025

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We report that L-GSH supplementation for 3 months in people with T2DM was able to reduce the levels of oxidative stress in all blood components and prevent depletion of glutathione (GSH) in this population known to be GSH deficient

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Int J Mol Sci 25:8273

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This can be related to neurochemical processes involved in neurotoxicity and pathogenesis in AUD

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