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Palmer, S

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In one phase Ib/II study, 19 patients with R/R AML received combination therapy with azacitidine and avelumab, another PD-L1 inhibitor, with a higher CRR of 10.5%, and two patients achieved CR with thrombocytopenia (Saxena et al., 2021)

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As enzyme activity measurements are done in excess substrate conditions, the expected high glucose-stimulated decrease in NADPH cellular availability cannot be the only reason for decreased activities