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The development of RNAi drugs and small molecule inhibitors targeting NNMT is facing several challenges

Low levels of insulin-like growth-factor-binding protein-1 (IGFBP-1) are prospectively associated with the incidence of type 2 diabetes and impaired glucose tolerance (IGT): the Sderkra Cardiovascular Risk Factor Study

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The main aetiologies can be divided under two main categories: inadequate dietary intake and impaired absorption of vitamin B 12 (Table 1)
