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Nature 507 , 323328 (2014)

However, these mechanisms underlying activation of mitochondrial ROS generation can be associated to a rewiring of the mitochondrial metabolism of tumor cells [e.g., MYC/KRAS or MYC/ERBB2 ablation in breast and pancreas cancer cells ( Effect of mROS on Tumor Initiation and Progression Mitochondria may contribute to malignant phenotype as mROS can lead to DNA aberrations and activation of oncogenic pathways

They identified, on average, higher levels of MDA and lower levels of GSH and FRAP in cases compared to controls, all of which align with a higher prooxidant and lower antioxidant profile within cases of PHG

[DOI] [PMC free article] [PubMed] [Google Scholar] 23.Wang Y, Quan F, Cao Q, Lin Y, Yue C, Bi R, Cui X, Yang H, Yang Y, Birnbaumer L, et al

On the other hand, transgenic lines with overexpression of GHRH [34, 35], human (h) GH [3642] or bovine (b) GH in mice, all show an excess of GH, increased body size, skeletal gigantism, and increased BMD [38, 4349]

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