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gradual titration reduces incidence [1] [5]

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The median relative percentage of B lymphocytes was significantly higher in both activated populations (CD86 high HLA-DR high : 17% (LC), 11% (CC) and 12% (HC)) and double-negative subsets (IgD CD27 CD24 CD38 : 5% (LC), 2% (CC) and 2% (HC)) (Extended Data Fig