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The plasma was separated under centrifugation at 10,000 rpm for 10 min at 4 and stored for further processing at 20

Ageing: Over time, the skins natural ability to regulate melanin weakens, leading to age spots

Hydroxytyrosol is the major anti-inflammatory compound in aqueous olive extracts and impairs cytokine and chemokine production in macrophages

Smoking is a major risk factor, as it accelerates damage to retinal cells

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One last thing worth knowing for context: Octinoxate has been the subject of ongoing review in Europe where the Scientific Committee on Consumer Safety's (SCCS) 2025 final opinion is that this ingredient is an endocrine-active substance