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However, a Cys286 TrxR mutant retained catalytic activity and auranofin susceptibility leading to the suggestion that it is a decoy site and binding is not fully dependent on this interaction

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In contrast, in the latest studies comparing hyperfractionated radiotherapy, conventionally fractionated radiotherapy, and hypofractionated radiotherapy, although relatively lower-fractionated radiotherapy may increase acute toxicity, there appears to be no significant difference in the long-term effects or late toxicity (105, 107112)

Interestingly however, all three variants are closely aligned within the so-called overlap region of the collagen fibril, in which molecules are staggered by multiples of D 37 (see Fig

In addition, erastin treatment also caused a time-dependent increase in iNOS total protein level, which peaked at approximately 10 h after erastin treatment (Fig