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Furthermore, sourcing introduces uncertainty in sterility and formulation integrity, which may represent a more immediate and clinically relevant risk than theoretical biologic effects, particularly given the potential for nonsterile preparation, contamination, or inconsistent formulation in nonregulated injectable products

estimated short plasma half-life typical of small peptides (minutes to low hours) 2

Activity in old mice macrophages was not influenced in a statistically important manner [47,48]

Yes and no