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Surprisingly, previous studies considered that ferroptotic cancers cells lack immunogenicity, which might impede the elicitation of properly processed and antigen presentation [232]

Several studies have shown that butyrate can inhibit the secretion of inflammatory factors such as IL-12 and TNF- through several signaling pathways such as NF-B, and most studies have concluded that the proportion of thick-walled bacterial phylum in the intestines of patients with ITP is on the decline, which is consistent with the pathogenesis of ITP

Butyrate bound the toll-like receptor 5 (TLR5), which resulted in NF-B activation and enhanced CD8 T cell function 56

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