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(January 1992)

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The ability of integrins to act as a bridge between the extracellular environment and cytoskeleton/signal protein kinases enables them to transmit inside-out and outside-in signals and to mediate both bidirectional force transmission and signal transduction via an allosteric mechanism by switching between active and inactive conformations [35, 36]

Statistical analysis For metabolomic analysis, metabolites were normalized with ribitol (internal standard), with logarithmic transformation and autoscaling to proceed with the statistical analysis