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4.2.3 Dual-substrate-competitive inhibitors Dual-substrate-competitive inhibitors compete with the both substrates (SAM and NAM) for the binding sites in NNMT, thereby increasing inhibitors activity and selectivity (Table 1 and Figure 6, such inhibitors mainly include MvH45 (Van Haren et al., 2017), AK-12 (Ruf et al., 2022), MS2756 ( MS2734 ( GYZ-78 ( NS1 ( LL320 ( CC-410 (Roberti et al., 2023)

[DOI] [PubMed] [Google Scholar] 15.Soohoo M., Ahmadi S.F., Qader H., Streja E., Obi Y., Moradi H., Rhee C.M., Kim T.H., Kovesdy C.P., Kalantar-Zadeh K

Family members who assist in the care of a client with a blood-borne infection such as HIV or hepatitis C can prevent transmission by carefully handling any sharp objects that are contaminated by blood