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Unlike GHRP-6 and hexarelin, which increase cortisol, prolactin, and appetite alongside GH release, ipamorelin is reported to produce GH release with minimal off-target hormonal effects, which is why it has become a preferred pharmacological tool for isolating GH-axis effects from cortisol and prolactin-related confounders in experimental design

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The best docking (binding free energy) scores for the four compounds ranged from 5.9kcal/mol (for Ferrostatin) to 7.6kcal/mol (for Lapatinib, Table 3)

It has decades of clinical use behind it, a well-understood side effect profile, and reliable results

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