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For example, the stimulation of nasal epithelial cells with PM2.5 can increase ROS production through CYP1A1 [49]

GSH as cysteine storage and the -glutamyl cycle Storage of cysteine is one of the most important functions of GSH because cysteine is extremely unstable extracellularly and rapidly auto-oxidizes to cystine, in a process that produces potentially toxic oxygen free radicals (Meister, 1988)

Recent studies reported that arginine-rich DPRs, such as poly(GR) and poly(PR), interact with LC domain-containing RBPs, including FUS, and alter their liquid-liquid phase separation, resulting in the disruption of the dynamics and functions of membraneless organelles (Kwon et al., 2014

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