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PT-141 enables selective pharmacological activation of hypothalamic MC4R pathways in both animal models and human neuroimaging studies [13, 15] Oxytocin neuroscience : Studying the melanocortin-oxytocin signaling axis in the PVN, including the mechanisms by which MC4R activation triggers oxytocinergic neuron firing and oxytocin release into both central and peripheral compartments [14, 23] Cyclic peptide drug design : PT-141's lactam bridge cyclization strategy serves as a paradigm for designing conformationally constrained peptides with enhanced target selectivity and metabolic stability
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