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[DOI] [PubMed] [Google Scholar] 199.Espinola E.B., Dias R.F., Mattei R., Carlini E.A

Russian Lee E, Lee SY, Hong SJ

Peptide therapeutics have emerged as promising agents in gerontological medicine, targeting multiple hallmarks of aging, including genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis (protein homeostasis), mitochondrial dysfunction, and cellular senescence ( This review examines nine peptides with demonstrated or potential applications in age-related conditions: tirzepatide, epitalon, GHK-Cu, BPC-157, TB-500, Semax, CJC-1295, ipamorelin, and bremelanotide (PT-141)

A 2025 review by Jozwiak and colleagues surveys the peptides multifunctionality and possible medical applications (PMC11859134), and is a useful map of what has and has not been established

Overall, the combination doesn't produce new, unique, or significantly amplified side effects compared to each medication alone