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doi:10.3390/cells13211799

GeroScience 43 , 10711081 (2021)

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Care must also be taken to ensure the absence of metals, especially iron, copper, manganese, and titanium, because these also behave as oxidizing agents for DHA

1 Introduction Glucocorticoids are essential hormones for vertebrate life that act via the glucocorticoid receptor (GR), a nearly ubiquitously expressed molecule with diverse functions throughout the body ( 2 Glucocorticoid physiology The synthesis and secretion of endogenous glucocorticoids are under the control of the hypothalamic-pituitary-adrenal (HPA) axis, which in turn is regulated by the diurnal circadian rhythm ( 2.1 Glucocorticoid receptor physiology: structure GR is encoded by the ~ 126-kb NR3C1 gene and is composed of nine exons ( Figure 1 ) ( Figure 1 In addition to the splice variants, GR has eight alternative translation initiation sites in exon 2, arising from leaky ribosomal shunting of the mRNA ( Figure 1 )

Hang, L