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Box A: Diversity of GPCR ligands Neurotransmitters norepinephrine adenosine histamine serotonin dopamine cannabinoids opiates acetylcholine GABA glutamate Peptide hormones endothelin glucagon angiotensin II GSH, FSH, CRH GnRH, ACTH Tastants, oderants, light Learning Objectives 1

The change from uncompetitive to non-competitive mechanism induced by chemical modifications of the inhibitors is not rare in drug design studies 48,49,50

Acknowledgements This research was partially supported by NSF grants DMS-0616710(MR, HFN) and EF-1038593(HFN, MR) and NIH grant R01 ES019876 (D

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Die Wirkung tritt bei Infusionen besonders schnell ein