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The examination of molecular pathways demonstrates that down-regulation of TGF-1/Smad3 axis mediates antifibrotic impact of this compound ( As it was mentioned earlier, DM is a chronic metabolic disorder with high incidence rate, demanding novel strategies in its treatment and management

A recent systematic review including 371 patients further corroborated these results, showing that FMT nearly tripled short-term survival at 1 and 3 months, although benefits beyond 6 months were not sustained [102]

The normal physiological ROS levels play an essential role in cell differentiation, proliferation, and migration ( 2 O 3 ) nanoparticles decreased oxidative stress and attenuated the mitochondrial stress and inflammatory markers in an AP rat model ( 2 O 3 nanoparticles, like catalase and superoxide dismutase mimetic, possess promising anti-oxidation properties ( During the trigger and development of AP, a variety of enzymes can be secreted by pancreatic tissues, such as proteolytic enzymes (Zhao et al., 2015)

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Rosner J, Samardzic T, Sarao MS