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Other than exogenous products, lifestyle interventions (such as diet modification and exercise prescription) are also biologically plausible to act as adjunctive therapies and should be further explored in preclinical models, particularly due to bias derived from behavioral modification in such clinical trials [59] (Figure 2)

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Cys is needed for the synthesis of GSH, which, in turn, allows GPX4 to reduce lipid peroxides

We also explored the expression of the Keap 1-Nrf2--antioxidant response element signaling pathway that is known to regulate several protective mechanisms, including the expression of antioxidant and anti-inflammatory events

Sodium selenite for treatment of Kashin-Beck disease in children: a systematic review of randomised controlled trials

Isoniazid Isoniazid, which is used for the treatment of tuberculosis (Ch
