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doi: 10.1096/fj.13-238725 128 Al-MansooriLAl-JaberHPrinceMSElrayessMA

In particular, impaired mitochondrial function in intestinal epithelial cells (IEC) is associated with reduced stemness and Paneth cell dysfunction 18,20,22

Mechanistically, flavonoids act by concurrently modulating multiple interconnected signaling pathways, reshaping the immune network in a mild yet sustained manner rather than strongly suppressing a single pathway

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Laboratory research has examined its interaction with nitric oxide (NO) pathways, growth factor modulation including VEGF and EGF, and the FAK-paxillin signaling cascade used in tissue remodeling studies