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These assessments can be incorporated into the SAD arm of the study when dose escalation has reached an anticipated therapeutically relevant level ( Figure 4), this is particularly important for drugs that exhibit nonlinear PK either based on preclinical PK data in animals or cumulative data from the ongoing trial as clinical PK data become available

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Detoxification If youre trying to reduce your toxic burden, sweating can help

PDE, PD Effluent