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Cognitive and Neurological Research Cognitive and neurological research in 28-month-old mice using 10 mg/kg body weight 5x per week for 3 weeks showed significantly faster escape hole finding in Box Maze tests with evidence of decreased brain inflammation and increased histone deacetylase 2 labeling

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Unlike other conditions, this one isnt directly caused by B12 deficiency

Possible genegender interaction between the SLCO1B1 polymorphism and statin treatment efficacy

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Polymorphisms in various genes involved in vitamin B 12 metabolism, including the genes encoding the intrinsic factor-cobalamin receptor (60) and the holo-transcobalamin receptor (61), have been associated with increased NTD risk in some studies