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PMID: 12649629
The mechanism of improvement in respiratory capacity mainly concerns the ETC because the medium in this assay contains glucose and pyruvic acid, but not glutamate or fatty acid (Supplementary Information)
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We propose a cellular model of CVS in which an aberrant ion gradient begets mitochondrial dysfunction which begets further anomalous ion gradients, etc., forming a pathogenic vicious cycle leading to cellular hyperexcitability (Figure 1)
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