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Its dual actionpromoting microglial polarization toward an anti-inflammatory phenotype and reversing ferroptosis markerspositions Cyn as a particularly attractive cycle-modulating agent

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Hippocampal Neuron-Enriched Cultures Primary neuronal cultures were established from 18-day-old embryonic rat hippocampi, as previously described ( 2 ) glass coverslips, previously coated with poly(D-lysine) (50 g/ml) and then with DMEM/HAM F12 containing 10% FCS

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Their high intake increases excitatory neurotransmission, generates ROS, and contributes to CNS oxidative stress [82]

The evidence base for IBD and leaky gut is more preliminary but biologically plausible given the mechanism