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Compared with saline and free-drug controls, TBP-NP-treated mice demonstrated significantly improved range of motion and enhanced mechanical properties, confirming effective tendon-specific targeting and functional repair ( In vitro , PDGF-BB cmRNA enhanced tendon cell proliferation and migration, while IL1RA cmRNA reduced pro-inflammatory cytokine expression

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*Disclaimer: This statement has not been evaluated by the FDA

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Although de novo polyamine synthesis from ornithine represents the major source of intracellular polyamines, transport of extracellular polyamines into cells is accomplished via the SLC45A4 encoded transporter which is a member of the glycoside-pentoside-hexuronide cation symporter family of transporters

This requires that the molecule be chemically modified without altering its therapeutic action, which is not always possible and needs to be optimised for each individual molecule