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Biological pathways in hormones can be disrupted through genes, toxins, or imbalance

Ischemic stroke-induced excessive zinc release from synaptic vesicles triggers excitotoxicity that moves into post-synaptic neurons through calcium-permeable channels, such as GluR and calcium-permeable AMPA/K (Ca-A/K)

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(PMID: 24684379) Ruttmann, Brant, Concin, and colleagues followed 163,944 Austrian adults for up to 17 years and published their findings in Circulation in 2005

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