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doi:10.1038/79936 pmid:11017079 Devi L, Raghavendran V, Prabhu BM, Avadhani NG, Anandatheerthavarada HK (2008) Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain

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Tyrosine is equally important for protein biosynthesis as well as an intermediate in the biosynthesis of the catecholamines: dopamine, norepinephrine, and epinephrine
We utilize this system to investigate the effect of the microbiome and aging on APAP toxicity, two variables that have proven difficult to definitively investigate in human or murine systems
