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Based on these findings, researchers have engineered pH/cathepsin B sequentially responsive NPs (PSRNs) conjugated with PROTACs targeting cyclin-dependent kinases 4 and 6 (CDK4/6), leveraging ultra-pH-sensitive and enzyme-responsive nanotechnology [129]

Injectable forms may also reduce the required dose because less degradation occurs prior to systemic absorption

Through consumption of NADPH, oxidative stress leads to the accumulation of large amounts of NADP + and subsequently to the activation of G6DP due to the increased concentration of oxidants (249)

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