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The genes encoding the three APR isoforms, in particular APR1 (At4g04610) and APR3 (At4g21990), were induced at all three time points, with a maximum after 1 h of allyl-ITC treatment

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In addition, oligodendrocyte lineage transcription factor 2 (Olig2) is located on chromosome 21 which is 6.8 Mb telomeric of the amyloid precursor protein (APP) gene

its intervention significantly increased the abundance of beneficial bacteria like Akkermansia muciniphila and regulated the host bile acid pool, indicating that specific gut microbes mediated the alleviation effect of obeticholic acid by regulating host bile acid metabolism

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10.1016/S1353-8020(11)70065-7