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Besides, 4-Hydroxynonenal (4-HNE), a major product of lipid peroxidation, is reported to induce the generation of ROS, which will aggravate the lipid peroxidation and ferroptosis, so 4-HNE can be a marker of ferroptosis as well [2224, 26]
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Several ferroptosis inducers have been identified that function by depleting intracellular GSH, inactivating GPX4, activating the mevalonate pathway, and increasing intracellular lipid peroxidation and iron content [18, 171, 254]
