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In healthy young adults (yellow curves), robust high-amplitude circadian rhythms are evident in diverse physiological variables (activity levels, core body temperature, SCN firing rate, hormonal secretion such as melatonin and cortisol, glucose metabolism, etc.) across the 24-h day

Besides, the tryptophan metabolites 3-hydroxy-kynurenine, 3-hydroxyanthranilic acid and quinolinic acid regulate oxidative stress processes, such as lipid peroxidation, and may act both in a pro-oxidative and anti-oxidative way (Nitz et al., 2019)

CIN, Contrast Induced Nephropathy

135:13781387 Calabrese G, Morgan B, Riemer J (2017) Mitochondrial glutathione: regulation and functions

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Although the initial drug concentrations in the brain were comparable between PBD-SLNs and PBD-SLN-ISGs, PBD-SLN-ISGs displayed higher drug concentrations than PBD-SLNs after 240 min