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Efficacy of Azacitidine Compared with That of Conventional Care Regimens in the Treatment of Higher-Risk Myelodysplastic Syndromes: A Randomised, Open-Label, Phase III Study

The PST-M or thermolabile (TL) isoform (encoded by the SULT1A genes, mainly SULT1A3/SULT1A4 ) is involved in the catabolism of bioamines (e.g., catecholamines or serotonin), whereas the PST-P or thermostable (TS) isoform (encoded by the SULT1A genes, mainly SULT1A1 and SULT1A2 ) is involved in the catabolism of small phenolic chemicals 20,21 , though both variants will sulfate alternative substrates at high concentrations 22