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Homeostasis of metals in the progression of Alzheimer's disease

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Acknowledgements This work was supported by the National Research Foundation of Korea (2013R1A2A2A04014661, Chung-KyoonAuh)

Membranes were visualized using WesternBright ECL HRP substrate (Advansta) or SuperSignal West Femto Maximum Sensitivity Substrate (Thermo Fisher Scientific) on a ChemiDoc TM Imaging System (Bio-Rad)

Therefore, the focus of NADs research and development has shifted toward improving nucleic acid modifications and developing efficient, safe, and targeted delivery systems

Addition of hydrophobic methyl group substitutions around the quinolinium scaffold (previously shown to negatively impact NNMT inhibitory activity) only slightly improved membrane permeability via passive transport as indicated by the low, but non-zero, permeability values for 1,8-diMQ and 1,2,4,8-tetraMQ (Table 4)