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Further studies by Isshiki focused on developing therapeutic strategies targeting profibrotic macrophages in interstitial lung disease 25

lysosomes remained intact, demonstrating selectivity of organelle targeting In vivo tumour eradication pre-clinical studies have reported tumour eradication in nude mouse xenograft models following PNC-27 treatment Ovarian cancer models intraperitoneal mouse toxicity and maximum tolerated dose studies conducted alongside ex-vivo testing against primary patient-derived epithelial ovarian cancer cultures, demonstrating dose-dependent cytotoxicity including activity against chemotherapy-resistant ovarian cancer lines Haematological malignancy models near-complete cancer cell death reported in leukaemia models, including p53-deficient cells, via HDM-2 membrane binding Cervical cancer models confirmed selective killing of cervical cancer cells with no effect on untransformed cervical cells

PCSK9 regulates pyroptosis via mtDNA damage in chronic myocardial ischemia

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269 XiaoA.ZhangY.RenY.ChenR.LiT.YouC.et al (2021)