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However, the foundational mechanism paper (Benoist et al., 2014 in J Pharmacol Exp Ther) establishing Dihexas HGF/c-Met pathway activation was formally retracted in April 2025 after being flagged since 2021

Traumatic injury or a fall onto an outstretched hand is the most common mechanism of injury

Patients are advised to include: Liver, chicken, and other meats Fish such as salmon and tuna Eggs and dairy products Fortified cereals and nutritional yeast for vegetarians Vitamin B12 Supplements Supplementation is often required and may include: Oral tablets Sublingual drops Nasal sprays Injections for severe or absorption-related deficiencies Vitamin B12 Deficiency Medication In conditions like pernicious anaemia, long-term or lifelong treatment (often injections) may be necessary, with frequency adjusted based on severity

doi: 10.1097/01.WCB.0000106012.33322.A2

Regardless of the cause, the diagnosis of B12 deficiency is complex and can present at all ages with a wide spectrum of symptoms

They cause osteoporosis and further weaken the bone