glutathione regulatory detoxification Frontiers Glutathione-Mediated Conjugation of Anticancer Drugs:

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It binds to guanine triphosphate (GTP), which results in the conformational changes that later trigger the signal transduction of different G-proteins: inhibitory G-protein (G i ), stimulatory G-protein (G s ), and guanine-nucleotide binding protein (G q ) (79)

This may be due to compensatory action of other antioxidant enzymes, since expressions of TRX, other members of PRX family and CAT were all upregulated in response to PRX-2 inhibition (Won et al

Jimnez-Atinzar, M., Escribano, J., Cabanes, J., Ganda-Herrero, F

Sun YL, Zhou FM, Wang HR