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Description
A GWAS in male Chinese participants revealed four loci (MSX2, CXCR5, PRKCE and MARCKS) associated with the presence of tophi, introducing novel and currently insufficiently explored genetic associations with gout

Zentralbl., 95 : 463-469

Reyes-Gonzalez JM, Armaiz-Pena GN, Mangala LS, Valiyeva F, Ivan C, Pradeep S, et al

Several factors determine whether you'll purge and how intensely

So they're very, very preserved, very powerful, and they're self-regenerative, meaning once they get triggered, they tend to keep going

Statements Author contributions ZL, and WX conceived and designed the review
