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It is involved in key metabolic pathways, including the tricarboxylic acid cycle, oxidative phosphorylation, and the metabolism of amino acids, fatty acids, and nucleotides (78, 79)

1 Although hepatic steatosis within NAFLD is a widespread disease, with prevalence in some parts of the world up to 40%, 2 NASH is present in only 10% to 20% of individuals with NAFLD, but when accompanied by significant fibrosis is associated with increased overall mortality, primarily from cardiovascular diseases

Diagnosing pathological fatigue necessitates the significant presence of fatigue, reduced energy, and a disproportionate need for rest relative to activity levels

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