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J Pediatr 155:623628

Granzyme K(+) cd8 T cells form a core population in inflamed human tissue

Yilmaz V

The vehicle (carrier) matters as much as the concentration for skin penetration

Mayrhofer et al., 2021)
The aqueous medium serves as a pool where protons can be parked when the transfer reaction is solely of electrons (the analogy borrowed from the very accessible introductory biochemistry book The chemistry of life by Steven Rose)