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In an effort to clarify the role of the KEAP1-NRF2 pathway in ALS, it has been revealed that the transfection of the mouse MN-like hybrid cell line (NSC-34) with the human SOD1 G93A gene causes damage in the Nrf2/ARE signalling and a reduced ability of cells to react to OS

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What patients usually notice People often describe the difference in functional terms: Smoother mornings: not always fast, but less abrupt

JL: Conceptualization, Funding acquisition, Supervision, Writing review & editing

When assessing for vitamin B12 deficiency, in addition to checking a vitamin B12 level, consider ordering a methylmalonic acid level or a holotranscobalamin level and CBC (to assess for red blood cell size)

Ferroptosis suppression contributes to resistance in BRCA-wild-type cancers, while PARPi-FIN combinations synergistically enhance cytotoxicity in BRCA-proficient ovarian cancer models both in vitro and in vivo