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These analyses are mainly non-invasive, but the selection of the ideal GSH S-conjugates as biomarkers should take into account their clear-cut correlation with the relevant disease, stability, half-life and method(s) for samples preparation

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This suggests that therapeutic research focusing on DYRK1A inhibition should, at least in part, also take care of the problem of CBS triplication, at the condition that these inhibitors are specific of DYRK1A and do not inhibit GSK3 as well, as our data suggest that GSK3 activation is needed to reduce Nrf2 activity and thus CBS expression

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NRF2 regulates mitochondrial redox homeostasis by several mechanisms such as detoxification of peroxides, regeneration of GSH, increased synthesis of GSH and NADPH and via the NRF2-Keap 1 response

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