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This comprehensive mechanism addresses appetite, energy expenditure, gastric function, and glucose homeostasis through distinct but complementary receptor systems, potentially explaining enhanced efficacy observed in combination approaches compared to monotherapies
Supplementary Tables 9 and 10)

The authors propose that amifostine may enhance p53-dependent protective effects by increasing nuclear accumulation, inhibiting degradation, and inducing transcription factors related to p53 expression [55]

It is one of the first inflammatory signals released when the immune system perceives a threat, and in psoriasis, it acts as a master switch that amplifies virtually every other inflammatory pathway involved

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