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Certain prescription medications, including antacids and anti-diabetic medicines like metformin can cause vitamin B12 deficiency An endocrine-related autoimmune disorder, such as thyroid disease or diabetes Eating a vegetarian or vegan diet and excessive consumption of alcohol Certain gastrointestinal disorders, such as Crohns disease or Gastric bypass surgery or removal of part of the stomach Brain related disorders such as anxiety, depression, irritability and even poor concentration and general restlessness Heart and blood-related problems, increased risk of infections, improper growth in children and complication during pregnancy If you are a strict vegetarian, take vitamin B12 supplements

I got some transdermal patches and used those quite successfully for some years

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Hi, I am low on B12 from last 2 years

may be bloody if colonic involvement Abdominal pain and cramping typically right lower quadrant (terminal ileal disease)