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Symptoms may include fatigue, weakness, memory problems, difficulty concentrating, mood changes, numbness or tingling in the hands and feet, and difficulty maintaining balance

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This dual mechanism is what makes it different from semaglutide and other single-receptor GLP-1 medications
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The American Society of Anesthesiologists (ASA) said in a recent statement that people who take the GLP-1 agonists every day should stop the medication on the day of the surgery

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By 104 weeks, approximately 77% of SELECT patients on dose were receiving the target semaglutide 2.4 mg weekly dose, which is lower than the corresponding proportion of patients in STEP 1 (89.6% were receiving the target dose at week 68) 14,21
